Non-alcoholic fatty liver disease, increasingly designated metabolic-associated fatty liver disease to better reflect its pathophysiological basis in metabolic dysfunction, has become the most prevalent chronic liver disease worldwide over the past three decades, a transformation driven by the parallel global epidemics of obesity, type 2 diabetes, and metabolic syndrome that have created the metabolic substrate […]
Viral hepatitis B and hepatitis C represent the two most clinically consequential viral infections of the liver, together responsible for the majority of chronic liver disease, cirrhosis, and hepatocellular carcinoma worldwide and generating a combined global mortality burden of approximately 1.3 million deaths annually that places them among the most deadly infectious diseases in human […]
Alcoholic liver disease encompasses the spectrum of hepatic injury produced by chronic and excessive alcohol consumption, ranging from the entirely reversible hepatic steatosis of early alcohol-related fatty liver through the more serious alcoholic hepatitis to the irreversible cirrhosis and its life-threatening complications that represent the endpoint of chronic alcohol-induced hepatic destruction. It is the most […]