Glomerulonephritis, the inflammatory disease of the glomerulus produced by immune-mediated injury to the filtration unit of the kidney, encompasses a diverse spectrum of conditions unified by the common pathological theme of inflammatory damage to the glomerular capillary tuft, the podocytes, and the surrounding mesangium, but distinguished by widely varying immunological mechanisms, histological patterns, clinical presentations, […]
The relationship between hypertension and kidney disease is one of the most clinically consequential bidirectional relationships in all of medicine, a mutually destructive cycle in which high blood pressure damages the kidney and damaged kidneys raise blood pressure in a progressive spiral that without effective intervention leads to end-stage renal disease, cardiovascular catastrophe, and premature […]
Diabetic nephropathy is the leading cause of chronic kidney disease and end-stage renal disease in most developed and increasingly in developing countries, accounting for approximately forty to fifty percent of all new cases of kidney failure requiring dialysis or transplantation and generating a burden of morbidity, mortality, and healthcare resource consumption that rivals the most […]